[The effect of glucose and mannitol on transperitoneal transport; in vitro studies]

The changes of peritoneal absorption and excretion of urea, uric acid and gentamicin caused by glucose or mannitol have been analysed. These modification were differentiated, depended on the type of transported molecule, used osmotic agent and time of its activity as well as transfer direction. For example, glucose caused the increase of uric acid absorption and the decrease of urea excretion by about 40%. In contrast, mannitol didn't change the uric acid transport, but lowered the bidirectional transfer of urea. The mean values of gentamicin transport diminished after application of glucose or mannitol. This lowering was smaller in comparison with isoosmolar conditions. The reasons of above modifications are complex. It supposes that in vitro the direct physical action of hyperosmolality, metabolic activity of glucose and membrane effect of gentamicin balanced the solvent drag process. Furthermore, the heterogenecity of glucose and mannitol influence on the transperitoneal compounds transport are related to the transport rates (mechanism) of the examined osmotic agents and/or their metabolic activity.