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Related Experiment Video

Updated: May 24, 2026

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
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Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

Genome-wide methylation analysis.

Alexander Unterberger1, Adrian M Dubuc, Michael D Taylor

  • 1Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada. unterberger.alexander@gmail.com

Methods in Molecular Biology (Clifton, N.J.)
|February 24, 2012
PubMed
Summary
This summary is machine-generated.

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Genomic methylation patterns are altered in diseases like cancer. Understanding these changes through various assays can reveal insights into tumorigenesis and potential new therapies.

Area of Science:

  • Epigenetics
  • Genomics
  • Cancer Biology

Background:

  • Genomic methylation alterations are key indicators in cancer and other diseases.
  • Understanding genome-wide methylation is crucial for cancer research and therapeutic development.

Purpose of the Study:

  • To describe techniques for examining genome-wide methylation patterns.
  • To highlight methods for assessing global and regional methylation changes.

Main Methods:

  • Luminometric Methylation Assay
  • Restriction Landmark Genome Scanning (RLGS)
  • Cytosine Extension Assay
  • Nucleotide Separation Assays (Nearest Neighbor Analysis, High-Performance Capillary Electrophoresis)
  • Infinium Methylation Assay

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Targeted DNA Methylation Analysis by Next-generation Sequencing

Published on: February 24, 2015

Related Experiment Videos

Last Updated: May 24, 2026

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
07:50

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

DNA Methylation: Bisulphite Modification and Analysis
12:34

DNA Methylation: Bisulphite Modification and Analysis

Published on: October 21, 2011

Targeted DNA Methylation Analysis by Next-generation Sequencing
08:38

Targeted DNA Methylation Analysis by Next-generation Sequencing

Published on: February 24, 2015

Main Results:

  • These techniques enable the characterization of genome-wide methylation.
  • Global and regional methylation changes can be determined.
  • Insights into methylation alterations in disease states are provided.

Conclusions:

  • Characterizing genomic methylation patterns is vital for understanding disease mechanisms.
  • The described techniques offer powerful tools for epigenetic research.
  • This knowledge can pave the way for novel cancer therapies.