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Related Concept Videos

DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
What is Gene Expression?01:36

What is Gene Expression?

A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then processed and...
What is Gene Expression?01:42

What is Gene Expression?

Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...

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Related Experiment Video

Updated: May 24, 2026

DNA Microarrays: Sample Quality Control, Array Hybridization and Scanning
09:27

DNA Microarrays: Sample Quality Control, Array Hybridization and Scanning

Published on: March 15, 2011

Microarray for epigenetic changes: gene expression arrays.

Hilary A A Colyer1, Richard N Armstrong, Ken I Mills

  • 1Haematology, Centre for Cancer Research and Cell Biology Belfast, Queen's University Belfast, Belfast, Northern Ireland, UK. hcolyer01@qub.ac.uk

Methods in Molecular Biology (Clifton, N.J.)
|February 24, 2012
PubMed
Summary
This summary is machine-generated.

Microarrays analyze epigenetic interactions, including DNA methylation and histone modifications. This helps understand how epigenetic changes regulate gene expression in cell models and patients.

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Last Updated: May 24, 2026

DNA Microarrays: Sample Quality Control, Array Hybridization and Scanning
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Area of Science:

  • Epigenetics and Genomics
  • Molecular Biology
  • Gene Regulation

Background:

  • Epigenetic mechanisms like DNA methylation and histone modifications play crucial roles in cellular function.
  • Understanding the interplay between these epigenetic marks and gene expression is vital for biological and medical research.

Purpose of the Study:

  • To investigate how epigenetic status influences cellular function through differential gene expression.
  • To explore the utility of microarrays in studying comprehensive epigenetic interactions.

Main Methods:

  • Utilizing microarray technology to assess global epigenetic changes.
  • Analyzing data from cell line models and patient comparisons.

Main Results:

  • Microarrays provide a comprehensive view of epigenetic alterations.
  • Differential gene expression patterns correlate with epigenetic status.

Conclusions:

  • Microarray analysis is a powerful tool for dissecting epigenetic regulation of gene expression.
  • This approach supports investigations into drug effects and patient stratification.