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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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Related Experiment Video

Updated: May 24, 2026

Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

Diet, epigenetics, and cancer.

L Joseph Su1

  • 1Division of Cancer Controls and Population Sciences, National Cancer Institute, Rockville, MD, USA. joseph.su@nih.gov

Methods in Molecular Biology (Clifton, N.J.)
|February 24, 2012
PubMed
Summary
This summary is machine-generated.

Diet significantly influences cancer development and epigenetics. Understanding the links between nutrition, epigenetics, and cancer progression is crucial for prevention and treatment strategies.

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Area of Science:

  • Oncology
  • Nutritional Science
  • Epigenetics

Background:

  • Cancer is a complex disease with diverse origins.
  • Epigenetic alterations are key drivers in cancer promotion and progression.
  • Diet plays a significant role in cancer etiology and epigenetic regulation.

Purpose of the Study:

  • To review the intricate relationship between cancer, nutrition, and epigenetics.
  • To highlight the impact of dietary factors on epigenetic mechanisms in carcinogenesis.

Main Methods:

  • Literature review of existing research on cancer, nutrition, and epigenetics.
  • Synthesis of current knowledge on dietary influences on epigenetic modifications.

Main Results:

  • Dietary components can modulate epigenetic marks, influencing cancer development.
  • Specific nutrients impact DNA methylation, histone modification, and microRNA expression.
  • These epigenetic changes are linked to the transition from cancer promotion to progression.

Conclusions:

  • Nutrition is a critical factor in cancer epigenetics.
  • Dietary interventions hold potential for cancer prevention and therapy by targeting epigenetic pathways.
  • Further research is needed to fully elucidate these complex interactions.