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Related Experiment Videos

When is an inhibitory synapse effective?

N Qian1, T J Sejnowski

  • 1Computational Neurobiology Laboratory, Salk Institute, La Jolla, CA 92037.

Proceedings of the National Academy of Sciences of the United States of America
|October 1, 1990
PubMed
Summary
This summary is machine-generated.

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Shunting inhibition is less effective on dendritic spines than previously modeled due to ion concentration changes. Hyperpolarizing inhibition via potassium (K+) currents is more effective on spines, suggesting GABAB receptors for cortical spine inhibition.

Area of Science:

  • Neuroscience
  • Computational Biology
  • Electrophysiology

Background:

  • Neuronal activity is shaped by excitatory and inhibitory synaptic inputs on dendrites.
  • Cable models predict shunting inhibition effectively vetoes excitatory inputs.
  • Cable models assume constant ionic concentrations, which may not hold for dendritic spines.

Purpose of the Study:

  • To analyze and simulate the effectiveness of shunting inhibition on dendritic spines using the Nernst-Planck electrodiffusion model.
  • To compare the predictions of the Nernst-Planck model with the traditional cable model.
  • To investigate alternative mechanisms for effective inhibition on dendritic spines.

Main Methods:

  • Analysis of electrodiffusion.
  • Computer simulations using the Nernst-Planck model.

Related Experiment Videos

  • Comparison with the cable equation model.

    • Main Results:

    • Shunting inhibition is less effective on spines than predicted by cable models due to significant intracellular chloride (Cl-) concentration changes.
    • These Cl- concentration changes alter the reversal potential and reduce the driving force for Cl-.
    • Hyperpolarizing inhibition via K+ currents is effective on spines for excitatory conductance changes < 10 nS.

    Conclusions:

    • Shunting inhibition is likely ineffective on dendritic spines but may be effective on dendritic shafts.
    • Effective inhibitory synapses on cortical spines are predicted to be mediated by K+ currents, possibly through GABAB receptors.