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Radical Autoxidation

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Assessment of Oxidative Damage in the Primary Mouse Ocular Surface Cells/Stem Cells in Response to Ultraviolet-C (UV-C) Damage
12:59

Assessment of Oxidative Damage in the Primary Mouse Ocular Surface Cells/Stem Cells in Response to Ultraviolet-C (UV-C) Damage

Published on: February 15, 2020

Cutaneous oxidative stress.

Thomas G Polefka1, Thomas A Meyer, Patricia P Agin

  • 1Life Science Solutions, LLC, Somerset, New Jersey, USA. tpolefka@lifescisolutions.com

Journal of Cosmetic Dermatology
|February 25, 2012
PubMed
Summary
This summary is machine-generated.

Microorganisms evolved 3.8 billion years ago, driven by sunlight and leading to oxygen production. This review explores cutaneous oxidative stress, its causes, and antioxidant defenses in aerobic organisms.

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Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
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Area of Science:

  • * Evolutionary biology
  • * Biochemistry
  • * Dermatology

Background:

  • * Microorganisms have existed for approximately 3.8 billion years.
  • * Photosynthetic organisms, driven by sunlight, produced oxygen, altering Earth's atmosphere and evolution.
  • * A 20% oxygen atmosphere presents challenges to aerobic organisms, especially the skin.

Purpose of the Study:

  • * To provide a comprehensive overview of cutaneous oxidative stress.
  • * To review nearly 40 years of research on the topic.
  • * To explain the origins, chemistry, and impact of free radicals and reactive oxygen species on the skin.

Main Methods:

  • * Literature review of scientific research on oxidative stress and skin.
  • * Synthesis of information on free radicals, reactive oxygen species, and antioxidant defenses.
  • * Examination of the role of oxygen in skin physiology and pathology.

Main Results:

  • * Free radicals and reactive oxygen species are byproducts of metabolic processes.
  • * These molecules can cause damage to skin cells and tissues.
  • * The skin possesses various antioxidant defense mechanisms to counteract oxidative stress.

Conclusions:

  • * Oxidative stress is a significant factor in skin aging and disease.
  • * Understanding the balance between reactive oxygen species and antioxidants is crucial for skin health.
  • * Further research into antioxidant therapies may offer protective benefits for the skin.