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Published on: February 13, 2018
Vasculitic neuropathy associated with minocycline use
Pariwat Thaisetthawatkul1, Robert Sundell, Carrie E Robertson
1Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198-2045, USA. pthaiset@unmc.edu
Introduction:
Minocycline is an antibiotic used for the treatment of acne. It has been associated with several autoimmune syndromes, including drug-induced lupus, autoimmune hepatitis, and vasculitis.
Method And Results:
We report a case of a 28-year-old previously healthy woman who developed a left sciatic mononeuropathy 2 weeks after starting minocycline for acne. Magnetic resonance imaging studies supported the localization. A biopsy of the left sural nerve revealed acute nerve large arteriole necrotizing vasculitis. Her condition improved after the withdrawal of minocycline and a course of treatment with methylprednisolone.
Conclusion:
This case provides further evidence that minocycline may induce a nonsystemic necrotizing vasculitis.
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