Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Next-generation chemogenetic inhibition using a brain-permeant non-prescription agent.

Signal transduction and targeted therapy·2026
Same author

UCL Queen Square Institute of Neurology: 75 years of innovation.

The Lancet. Neurology·2026
Same author

Clinical and Molecular Genetic Characterization of Landau Kleffner Syndrome: An Observational Cohort and Experimental Study.

Annals of neurology·2025
Same author

Deciphering temporal gene expression dynamics during epilepsy development using a rat model of focal neocortical epilepsy.

Epilepsia·2024
Same author

Early developmental alterations of CA1 pyramidal cells in Dravet syndrome.

Neurobiology of disease·2024
Same author

Structure-function and pharmacologic aspects of ion channels relevant to neurologic channelopathies.

Handbook of clinical neurology·2024
Same journal

Neural timescales from a computational perspective.

Nature neuroscience·2026
Same journal

Author Correction: Spinal cord Tau pathology induces tactile deficits and cognitive impairment in Alzheimer's disease via dysregulation of CCK neurons.

Nature neuroscience·2026
Same journal

Hippocampal theta sweeps indicate goal direction during navigation.

Nature neuroscience·2026
Same journal

Just how goal-directed are hippocampal theta sweeps, anyway?

Nature neuroscience·2026
Same journal

Goal-directed hippocampal theta sweeps during memory-guided navigation.

Nature neuroscience·2026
Same journal

Connectomic evidence that ordered activity drives neuromuscular network formation.

Nature neuroscience·2026
See all related articles

Related Experiment Video

Updated: May 24, 2026

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
10:59

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

Mapping out hippocampal inhibition.

Iris Oren1, Dimitri M Kullmann

  • 1University College London Institute of Neurology, London, UK.

Nature Neuroscience
|February 25, 2012
PubMed
Summary
This summary is machine-generated.

Researchers are combining optogenetics and pharmacogenetics to understand how hippocampal interneurons shape environmental navigation. This approach reveals how specific neuron types control information flow for spatial mapping.

More Related Videos

Horizontal Hippocampal Slices of the Mouse Brain
08:59

Horizontal Hippocampal Slices of the Mouse Brain

Published on: September 22, 2020

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice
07:10

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice

Published on: July 1, 2018

Related Experiment Videos

Last Updated: May 24, 2026

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
10:59

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

Horizontal Hippocampal Slices of the Mouse Brain
08:59

Horizontal Hippocampal Slices of the Mouse Brain

Published on: September 22, 2020

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice
07:10

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice

Published on: July 1, 2018

Area of Science:

  • Neuroscience
  • Computational Neuroscience

Background:

  • The hippocampus is crucial for spatial memory and environmental navigation.
  • Interneurons play a key role in regulating neuronal network activity and information processing within the hippocampus.

Purpose of the Study:

  • To investigate the functional roles of distinct hippocampal interneuron populations in directing sensory information.
  • To elucidate the mechanisms by which interneurons contribute to the formation of cognitive maps.

Main Methods:

  • Utilizing a combination of optogenetics and pharmacogenetics to precisely control and monitor interneuron activity.
  • Employing in vivo electrophysiology and behavioral paradigms to assess the impact of interneuron manipulation on spatial navigation.

Main Results:

  • Specific interneuron subtypes were found to differentially modulate the flow of sensory input to hippocampal circuits.
  • Targeted activation or inhibition of these interneurons significantly altered the animal's ability to form and utilize environmental maps.

Conclusions:

  • Opto- and pharmacogenetics provide powerful tools for dissecting the complex roles of interneurons in hippocampal function.
  • Interneuron-mediated regulation of information processing is fundamental to creating neural representations of the environment.