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Updated: May 24, 2026

Novel Sequence Discovery by Subtractive Genomics
09:40

Novel Sequence Discovery by Subtractive Genomics

Published on: January 25, 2019

Unrecognized sequence homologies may confound genome-wide association studies

Pierre Galichon1, Laurent Mesnard, Alexandre Hertig

  • 1INSERM UMR S702, Université Pierre et Marie Curie - Paris 6, 75006 Paris, France. galichon@orange.fr

Nucleic Acids Research
|February 25, 2012
PubMed
Summary

Previously unrecognized sequence homologies can mislead genome-wide association studies (GWAS). This study reveals how single-nucleotide polymorphism (SNP) microarrays may incorrectly link phenotypes to genetic loci, impacting common disease research.

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