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Related Concept Videos

Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...

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Related Experiment Video

Updated: May 24, 2026

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
07:39

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

Published on: June 28, 2019

Nevus senescence.

Andrew L Ross1, Margaret I Sanchez, James M Grichnik

  • 1Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

ISRN Dermatology
|February 25, 2012
PubMed
Summary
This summary is machine-generated.

Melanoma growth arrest is mediated by cellular senescence pathways, primarily p16. Overcoming these pathways, through gene deletion or repression, allows melanoma progression, suggesting reactivation could inhibit tumors.

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A Sensitive Method to Quantify Senescent Cancer Cells
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SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
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SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

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A Sensitive Method to Quantify Senescent Cancer Cells
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A Sensitive Method to Quantify Senescent Cancer Cells

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Area of Science:

  • Oncology
  • Cell Biology
  • Dermatology

Background:

  • Melanomas and nevi share growth mutations, but melanomas exhibit relentless growth while nevi stabilize.
  • The differential growth potential is linked to the activation of cellular senescence pathways.

Purpose of the Study:

  • To investigate the role of cellular senescence pathways in the growth arrest of nevi and the progression of melanomas.
  • To identify key mediators and mechanisms of senescence evasion in melanoma.

Main Methods:

  • Comparative analysis of senescence pathway activation in melanomas versus nevi.
  • Investigation of genetic and transcriptional alterations leading to senescence circumvention in melanoma.
  • Exploration of potential therapeutic strategies targeting senescence pathways.

Main Results:

  • p16 is identified as the primary mediator of senescence in nevi.
  • Redundant senescence pathways, including p14-p53-p21, IGFBP7, FBXO31, and PI3K-mediated ER stress response, are present in nevi.
  • Melanoma circumvents these senescence pathways via gene deletion or transcriptional repression.

Conclusions:

  • Cellular senescence pathways are critical for the growth arrest of benign nevi.
  • Melanoma progression is associated with the circumvention of these senescence mechanisms.
  • Reactivation of senescence pathways presents a potential therapeutic strategy to inhibit melanoma tumor progression.