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Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
The Nucleolus02:55

The Nucleolus

The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
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Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

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Updated: May 24, 2026

Utilization of Ultrasound Guided Tissue-directed Cellular Implantation for the Establishment of Biologically Relevant Metastatic Tumor Xenografts
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Nevogenesis: a benign metastatic process?

Andrew L Ross1, Margaret I Sanchez, James M Grichnik

  • 1Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.

ISRN Dermatology
|February 25, 2012
PubMed
Summary
This summary is machine-generated.

Cutaneous nevogenesis, the development of moles, may involve systemic processes beyond localized skin events. Circulating nevocytes suggest benign metastatic pathways could contribute to mole formation.

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Published on: August 25, 2021

Area of Science:

  • Dermatology
  • Pathology
  • Cell Biology

Background:

  • Traditionally, nevogenesis (mole development) is considered a localized process within the skin's dermis and epidermis.
  • Recent findings indicate the presence of nevocytes (mole cells) in peripheral blood.

Purpose of the Study:

  • To explore the theoretical role of systemic processes in nevogenesis.
  • To review the potential involvement of lymphatic and hematogenous dissemination of nevus progenitor cells.

Main Methods:

  • Literature review and theoretical analysis.
  • Examination of existing data on nevocyte circulation.
  • Analysis of proposed mechanisms for benign metastatic processes.

Main Results:

  • The presence of circulating nevocytes challenges the localized nevogenesis model.
  • Lymphatic and hematogenous spread of immature nevus progenitor cells is a plausible mechanism.

Conclusions:

  • Systemic dissemination may play a role in the development of certain types of nevi, such as nodal nevi and eruptive melanocytic nevi.
  • Further research is needed to confirm the systemic contribution to nevogenesis.