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Updated: May 24, 2026
06:35
Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
Published on: June 28, 2021
[Chronic pancreatitis: microbe-intestinal tissue complex and systemic inflammatory response]
Summary
Chronic pancreatitis treatment is improving, with prebiotics enhancing gut health and reducing systemic inflammation. This approach boosts therapy effectiveness for patients experiencing chronic pancreatitis.
Area of Science:
- Gastroenterology
- Microbiology
- Immunology
Background:
- Rising chronic pancreatitis incidence and declining therapy efficacy in the Russian Federation.
- Ineffectiveness of traditional treatments in reducing inflammation, correcting gut dysbiosis, and managing chronic inflammation.
- Pancreatic inflammation is linked to pro- and anti-inflammatory cytokine imbalance, increased pathogenic gut microbiota, and gut permeability.
Purpose of the Study:
- To evaluate the clinical efficacy of a complex treatment regimen for chronic pancreatitis.
- To assess the impact of this regimen on chronic systemic inflammation.
- To investigate the role of prebiotics in modulating gut dysbiosis and systemic inflammation.
Main Methods:
- A complex treatment regimen including proton pump inhibitors (PPI), spasmolytics, multienzymes, and prebiotics.
- Assessment of clinical outcomes in patients with chronic pancreatitis.
- Monitoring of chronic systemic inflammation markers and gut microbial-tissular complex changes.
Main Results:
- The efficacy of the complex treatment regimen is associated with its influence on chronic systemic inflammation.
- Addition of prebiotics significantly potentiates the correction of gut dysbiosis.
- Prebiotic therapy demonstrably reduces the grade of systemic inflammation in chronic pancreatitis patients.
Conclusions:
- A modern complex treatment regimen, particularly with prebiotic supplementation, enhances chronic pancreatitis therapy.
- Prebiotics play a crucial role in restoring gut microbial balance and mitigating systemic inflammation.
- Optimizing gut health via prebiotics is key to improving treatment outcomes for chronic pancreatitis.
Related Concept Videos
01:24Chronic Pancreatitis I: Introduction
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
01:25Chronic Pancreatitis I: Introduction
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
01:21Chronic Pancreatitis II: Pathophysiology
Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
01:21Acute Pancreatitis II: Pathophysiology
The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
01:25Acute Pancreatitis I: Introduction
Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
01:27Acute Pancreatitis I: Introduction
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include: