Related Experiment Video

Updated: May 24, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Treatment outcome of dogs with meticillin-resistant and meticillin-susceptible Staphylococcus pseudintermedius

Jacqueline Bryan1, Linda A Frank, Barton W Rohrbach

  • 1Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA. jbryan37@utk.edu

Veterinary Dermatology
|February 28, 2012
PubMed
Abstract

Insights

Canine pyoderma caused by meticillin-susceptible Staphylococcus pseudintermedius (MSSP) and meticillin-resistant Staphylococcus pseudintermedius (MRSP) generally resolves. Chloramphenicol use in MRSP cases was linked to more adverse effects and longer treatment durations.

Area of Science:

  • Veterinary Dermatology
  • Antimicrobial Resistance
  • Canine Health

Background:

  • Increasing prevalence of meticillin-resistant Staphylococcus pseudintermedius (MRSP) in canine pyoderma presents treatment challenges.
  • Canine pyoderma requires effective treatment strategies for both susceptible and resistant bacterial strains.

Purpose of the Study:

  • Compare treatment outcomes for canine pyoderma caused by meticillin-susceptible S. pseudintermedius (MSSP) and MRSP.
  • Evaluate adverse effects and concurrent factors in dogs with MSSP and MRSP pyoderma.

Main Methods:

  • Retrospective review of medical records from January 2008 to April 2010.
  • Inclusion of 123 MSSP and 93 MRSP canine pyoderma cases.
  • Analysis of clinical resolution, treatment duration, and adverse drug reactions.

Main Results:

  • Cefalexin and cefpodoxime were common for MSSP; chloramphenicol and doxycycline for MRSP.
  • Adverse effects, mainly gastrointestinal, were more frequent in MRSP cases (31/93) than MSSP (7/123).
  • Chloramphenicol was associated with the highest incidence of adverse reactions (27/51).

Conclusions:

  • Most canine pyodermas resolved irrespective of meticillin susceptibility.
  • Longer treatment duration in MRSP cases may relate to chronicity rather than the organism itself.
  • Chloramphenicol administration frequently led to adverse effects in dogs.

Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...