From phenomenon to mechanism: an investigational strategy

1. The author describes an investigational strategy useful in the field of psychopharmacology. 2. This strategy is based on the ability of a multi-disciplinary team first to measure significant changes in a behavioral or physiological variable in response to an experimental manipulation. 3. This initial measurement allows investigators to identify a phenomenon but not its underlying mechanism. 4. Study then proceeds to assess the anatomical substratum essential to mediating the physiologic change and receptology. 5. Finally, changes in second messenger mechanisms are determined. 6. Study of the neurobiologic effects of bright light is used as an illustration.