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[Clinical analysis of 53 cases of septicemia caused by Streptococcus viridans in children]
J Szymborski1, M Komar, G Kowalik
1Ze specjalistycznego Zespołu Opieki Zdrowotnej nad Matka i Dzieckiem w Wałbrzychu.
Insights
Streptococcus viridans sepsis frequently affects infants and young children. Most strains show high resistance to cloxacillin, with significant resistance to penicillin and ampicillin, impacting treatment outcomes.
Area of Science:
- Pediatric Infectious Diseases
- Microbiology
- Clinical Medicine
Background:
- Sepsis is a life-threatening condition, and Streptococcus viridans is an identified pathogen.
- Understanding the clinical characteristics and antimicrobial resistance patterns of S. viridans sepsis is crucial for effective management, especially in pediatric populations.
Observation:
- A clinical analysis of 53 cases of sepsis caused by Streptococcus viridans was conducted.
- The majority of pediatric sepsis cases, particularly in older infants and children up to 2 years, were attributed to S. viridans infection.
- Pulmonary localization was the most frequent clinical manifestation observed.
Findings:
- Isolated S. viridans strains exhibited high resistance: 90% to cloxacillin, 70% to penicillin, and 50% to ampicillin.
- Resistance to gentamicin was observed in 34% of isolates.
- Common laboratory findings included anemia and toxic granulation in neutrophils.
- The mortality rate was 7.5%, with four deaths reported.
Implications:
- The high antimicrobial resistance rates necessitate careful antibiotic selection for S. viridans sepsis in children.
- Early diagnosis and recognition of clinical and laboratory signs are vital for improving patient outcomes.
- Further research into effective treatment strategies for resistant S. viridans infections is warranted.
Abstract:
The clinical analysis has been performed in 53 cases of sepsis induced by Streptococcus viridans. Among children with diagnosis of sepsis majority of cases in group of older infant and children up to 2 year age was due to above infection. The S. viridans strain isolated form the blood were in 90% percentage resistant to cloxacillin , the resistance to penicillin, ampicillin and gentamicin was equal to 70%, 50% and 34% respectively. The main symptoms of the S. viridans sepsis was most frequently localized in lung. Laboratory findings most frequently revealed anemia and toxic granulation in neutrophils . Four children died due to the infection (mortality index to 7.5%).