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Updated: May 24, 2026
Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells
Published on: September 1, 2010
Cyto-morphologic evaluation of bone marrow in infants with disseminated neuroblastoma
Stefania Sorrentino1, Cristina Rosanda, Stefano Parodi
1Department of Haematology-Oncology, Giannina Gaslini Children's Hospital, National Cancer Research Institute, Genova, Italy. sorryste@gmail.com
Abstract:
We studied the prevalence and degree of tumor cell infiltration (TCI) in bone marrow (BM) aspirates of 89 infants with stage 4/4 S neuroblastoma and correlated them with MYCN gene status and patient outcome. TCI was scored 0, +, ++, and +++, the last corresponding to an infiltration greater than 10%. TCI 0 was more frequent in stage 4 than in stage 4 S. TCI + and ++ were equally represented. TCI +++ was found only in 9 patients, all with typical stage 4 features (bone or lung involvement). Overall survival was not significantly influenced by the presence and degree of TCI.
