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Diagonal Method to Measure Synergy Among Any Number of Drugs
Published on: June 21, 2018
Two is company, three is a crowd
Prabhat Hebbar1, Abhishek Deshmukh, Sadip Pant
1Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Journal of Cardiovascular Medicine (Hagerstown, Md.)
|February 28, 2012
Summary
Superior Vena Cava (SVC) syndrome, previously linked to malignancy, is now frequently caused by intravascular devices like pacemakers and central venous catheters (CVC). This case highlights SVC syndrome in a young patient with a pacemaker who received a CVC.
Area of Science:
- Cardiology
- Vascular Surgery
- Medical Device Technology
Background:
- Superior Vena Cava (SVC) syndrome is a clinical condition often associated with malignant tumors.
- The incidence of SVC syndrome has shifted, with intravascular devices now accounting for a significant proportion of cases.
- Pacemakers and implantable cardioverter-defibrillators (ICDs) are increasingly implicated in SVC syndrome.
Observation:
- A young patient with a history of permanent pacemaker implantation presented with SVC syndrome.
- The patient underwent central venous catheter (CVC) placement prior to surgery for hypertrophic cardiomyopathy.
- This case underscores the potential complications associated with indwelling vascular devices.
Findings:
- The patient's presentation of SVC syndrome was linked to the presence of both a pacemaker and a recently placed CVC.
- This case illustrates a non-malignant etiology of SVC syndrome in a patient with multiple intravascular devices.
- The temporal relationship between device placement and symptom onset suggests a causal link.
Implications:
- Clinicians should maintain a high index of suspicion for SVC syndrome in patients with pacemakers or CVCs, even in the absence of malignancy.
- Early recognition and management of device-related SVC syndrome are crucial for patient outcomes.
- Further research into preventative strategies and optimal management of device-associated SVC syndrome is warranted.
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