Related Experiment Video
Updated: May 24, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
Syndrome of inappropriate antidiuretic hormone secretion in patients with olfactory neuroblastoma
Stacey T Gray1, Eric H Holbrook, Mohammed H Najm
1Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA. Stacey_gray@meei.harvard.edu
Objective:
The syndrome of inappropriate antidiuretic hormone secretion (SIADH) has been reported as a paraneoplastic syndrome in many different types of malignancies. Several case reports of SIADH have been reported in patients with olfactory neuroblastoma (ONB), but the exact incidence is unknown. The purpose of this study was to review our experience with olfactory neuroblastoma and to identify all patients who had a history of SIADH prior to the diagnosis of ONB.
Study Design:
Case series and chart review.
Setting:
Tertiary care university-affiliated medical center.
Subjects And Methods:
A total of 21 patients presented to our institution with ONB between 1997 and 2009. All records were reviewed for a history of preoperative hyponatremia or SIADH.
Results:
Three patients were identified who had a history of SIADH prior to the diagnosis of ONB. Immunohistochemical staining of the tumor specimens from the 3 patients with SIADH was positive for arginine vasopressin. SIADH resolved in all 3 patients after successful treatment of ONB.
Conclusion:
Although uncommon, SIADH can be the presenting symptom of ONB and should be considered during the workup for idiopathic SIADH.
Related Concept Videos
Diabetes Insipidus II: Pathophysiology
Diabetes Insipidus I: Introduction
Olfactory Receptors: Location and Structure
Olfaction
The olfactory receptors are embedded in the cilia of the...
Physiology of Smell and Olfactory Pathway
The olfactory...
Renal Tubule and Collecting Duct
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...

