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[Clinico-hematological evaluation of 57 patients undergoing antiaggregant treatment with indobufen]
A Andriani1, G Mosiello, M G Chiappetta
1Ospedale San Giacomo, USL RM 1, Roma.
Insights
Long-term Indobufen administration effectively inhibited platelet function in cardiovascular patients. While generally safe, minor side effects like gastric issues and allergic reactions occurred, necessitating careful monitoring.
Area of Science:
- Cardiovascular Medicine
- Pharmacology
- Hematology
Background:
- Cardiovascular diseases necessitate treatments to prevent thrombotic events.
- Platelet aggregation plays a critical role in cardiovascular pathology.
- Antiplatelet agents are crucial in managing cardiovascular conditions.
Purpose of the Study:
- To evaluate the long-term efficacy and safety of Indobufen in cardiovascular patients.
- To assess the impact of Indobufen on platelet aggregation.
- To determine optimal dosage and monitoring strategies for Indobufen therapy.
Main Methods:
- A long-term study involving 57 cardiovascular disease patients.
- Daily administration of Indobufen at a 400 mg dosage.
- Platelet aggregation assays using ADP, collagen, and epinephrine.
- Clinical evaluation and monitoring for side effects and compliance.
Main Results:
- Significant and persistent inhibition of platelet aggregation was observed.
- Indobufen demonstrated effectiveness in reducing platelet function.
- Minor adverse events were reported, including gastric issues, occult blood, and allergic reactions.
- Drug withdrawal was necessary in 6 patients due to side effects.
Conclusions:
- Long-term Indobufen therapy is effective in inhibiting platelet function in cardiovascular patients.
- Clinical evaluation and platelet aggregation studies are vital for monitoring Indobufen's effectiveness, safety, and dosage.
- Careful patient monitoring is recommended to manage potential side effects.
Abstract:
A long-term administration of Indobufen, 400 mg daily, was evaluated in 57 patients with cardiovascular diseases. Aggregation waves induced by ADP, collagen and epinephrine showed a significant and persistent inhibition of platelet function. Minor side effects were observed and in 6 patients the drug was withdrawn: 4 patients began to experience gastric troubles, 1 patient had positive occult test for blood, 1 patient developed an allergic rush. Clinical evaluation and platelet aggregation study before starting indobufen and during the follow up period seem to be useful in the evaluation of effectiveness, safety, compliance and suitable daily dose.