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Related Experiment Video

Updated: May 24, 2026

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Transcriptome changes in age-related macular degeneration.

S Scott Whitmore¹, Robert F Mullins

¹Department of Ophthalmology and Visual Sciences, The University of Iowa Carver College of Medicine, 4135E MERF, 375 Newton Rd, Iowa City, IA 52242, USA.

|February 29, 2012

Summary

Researchers profiled molecular changes in age-related macular degeneration (AMD). This study provides comprehensive gene expression data for AMD tissues, aiding future research into the blinding disease.

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A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

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Last Updated: May 24, 2026

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

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Published on: May 26, 2023

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

Area of Science:

Ophthalmology
Genomics
Molecular Biology

Background:

Age-related macular degeneration (AMD) is a leading cause of vision loss.
The molecular underpinnings of AMD remain incompletely understood.
Previous research has not systematically profiled gene expression in AMD tissues.

Purpose of the Study:

To conduct the first systematic transcriptional profiling of AMD-affected tissues.
To generate comprehensive gene expression data across different ocular regions, tissue types, and disease stages.
To establish a foundation for systems-level research into AMD pathogenesis.

Main Methods:

Systematic transcriptional profiling of human ocular tissues.
Analysis of gene expression data from macula versus periphery.
Comparison of retina versus retinal pigment epithelium/choroid.
Assessment of gene expression in control versus early or advanced AMD states.

Main Results:

Comprehensive gene expression dataset for AMD-affected tissues.
Identification of distinct transcriptional profiles based on tissue region and disease state.
Detailed molecular data differentiating healthy and AMD-affected ocular tissues.

Conclusions:

The study provides a foundational resource for understanding AMD at a molecular level.
The generated data will facilitate further systems-level investigations into AMD pathogenesis.
This research opens new avenues for exploring the molecular basis of this blinding condition.