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The Periodic Table and Organismal Elements01:27

The Periodic Table and Organismal Elements

Elements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally occurring, and only a few of them are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.
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Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
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Published on: June 17, 2015

Low-level mercury exposure and peripheral nerve function.

Alfred Franzblau1, Hannah d'Arcy, Miriam B Ishak

  • 1University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109-2029, USA. afranz@umich.edu

Neurotoxicology
|February 29, 2012
PubMed
Summary
This summary is machine-generated.

This study found no consistent effect of urine mercury on sensory nerve function in dental professionals, even at levels overlapping the general population. Peripheral neurotoxicity was not observed.

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Area of Science:

  • Occupational Health
  • Neurotoxicology
  • Environmental Health

Background:

  • Mercury is a known neurotoxin, but its effects at background exposure levels are less understood.
  • Peripheral neurotoxicity from elemental mercury exposure requires further investigation, particularly in occupational settings.

Purpose of the Study:

  • To investigate the association between urinary mercury concentration and peripheral nerve function.
  • To assess sensory nerve conduction in dental professionals with varying mercury exposure levels.

Main Methods:

  • Utilized data from 2656 dental professionals collected between 1997-2006.
  • Measured urinary mercury and performed sensory nerve conduction studies on median and ulnar nerves.
  • Employed linear regression models to analyze the relationship between mercury levels and nerve function.

Main Results:

  • Urinary mercury levels in dental professionals overlapped with, but were generally higher than, the general population.
  • A significant positive association was found between urine mercury and median sensory peak latency in specific models.
  • No significant association was observed between urine mercury and nerve amplitudes.

Conclusions:

  • No consistent evidence of peripheral sensory nerve dysfunction was found in relation to urinary mercury levels.
  • The study suggests that at exposure levels overlapping the general population, mercury does not significantly impact objectively measured sensory nerve function.