Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Protein Folding

Protein Folding

Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...

Protein Folding

Protein Folding

Protein Folding

Protein Folding

Protein Folding Quality Check in the RER

Protein Folding Quality Check in the RER

ER is the primary site for the maturation and folding of soluble and transmembrane secretory proteins. The calnexin cycle is a specific chaperone system that folds and assesses the confirmation of N-glycosylated proteins before they can exit the ER lumen. The primary players of this quality check pipeline are the lectins, ER-resident chaperones, and a glucosyl transferase enzyme. In case the calnexin system in the lumen fails to salvage a misfolded protein, it is transported to the cytoplasm...

Conservation of Protein Domains Over Different Proteins

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain. Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...

Protein and Protein Structure

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Search for dijet resonances in 7 TeV pp collisions at CMS.

Physical review letters·2011

Same author

Search for quark compositeness with the dijet centrality ratio in pp collisions at √s=7 TeV.

Physical review letters·2011

Same author

Opacification of lenses cultured in the presence of Pb.

Molecular vision·2010

Same author

[Expression and significance of Fas/APO-1 and Bcl-2 protein in human lung cancer.].

Zhongguo fei ai za zhi = Chinese journal of lung cancer·2010

Same author

Whole-body diffusion-weighted imaging in lymphoma.

Cancer imaging : the official publication of the International Cancer Imaging Society·2010

Same author

Active-fiber star coupler that uses arrays of microlenses and liquid-crystal modulators.

Applied optics·2010

Same journal

Diallel crosses for resistance to Macrophomina phaseolina and Thanatephorus cucumeris on cowpea.

Genetics and molecular research : GMR·2017

Same journal

Diversity among elephant grass genotypes using Bayesian multi-trait model.

Genetics and molecular research : GMR·2017

Same journal

Coupled transcript and metabolite identification: insights on induction and synthesis of resveratrol in peanut, wild relatives and synthetic allotetraploid.

Genetics and molecular research : GMR·2017

Same journal

Estimates of genetics and phenotypics parameters for the yield and quality of soybean seeds.

Genetics and molecular research : GMR·2017

Same journal

In silico modeling and characterization of phytoparasitic nematodes translationally-controlled tumor proteins.

Genetics and molecular research : GMR·2017

Same journal

Molecular identification of variety purity in a cotton hybrid with unknown parentage using DNA-SSR markers.

Genetics and molecular research : GMR·2017

See all related articles

Search research articles

Related Experiment Video

Updated: May 24, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Improved method for predicting protein fold patterns with ensemble classifiers.

W Chen¹, X Liu, Y Huang

¹School of Information Science and Technology, Xiamen University, Xiamen, Fujian, China.

Genetics and Molecular Research : GMR

|February 29, 2012

Summary

This summary is machine-generated.

Predicting protein folding patterns is complex. Ensemble classifiers using 20-dimensional features improved accuracy to 77%, outperforming traditional methods for protein structure prediction.

More Related Videos

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Published on: July 8, 2025

Related Experiment Videos

Last Updated: May 24, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Published on: July 8, 2025

Area of Science:

Biophysics
Computational Biology
Bioinformatics

Background:

Protein folding is a critical challenge in 21st-century biophysics.
Predicting protein folding patterns is difficult due to the intricate structures of proteins.

Purpose of the Study:

To enhance the accuracy of protein folding pattern prediction.
To explore the efficacy of ensemble classifiers in this prediction task.

Main Methods:

Extracted 188-dimensional features based on protein composition and physicochemical properties.
Selected 20-dimensional features using a coupled position-specific scoring matrix.
Employed ensemble classifiers for improved prediction accuracy.

Main Results:

The 188-dimensional feature method achieved 71.2% accuracy via five cross-validations.
The 20-dimensional feature vector method reached 77% accuracy.
Application to recent data yielded 54.2% accuracy.

Conclusions:

Ensemble classifiers, particularly with reduced feature sets, offer superior protein folding prediction accuracy compared to traditional methods.
The developed methods and resources are valuable for advancing protein structure prediction research.