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Published on: March 14, 2019
Amplifications of NCOA3 gene in colorectal cancers in a Chinese population
Zhi Li1, Zheng-Yu Fang, Yi Ding
1Department of Histology and Embryology, Basic Medical College of Zhengzhou University, Zhengzhou 450001, Henan Province, China.
Aim:
To investigate the copy number variation of NACO3 gene in colorectal cancer (CRC) and its correlation with tumor progression.
Methods:
A total of 142 samples of case-matched CRC tissues and adjacent normal tissues were obtained from patients undergoing bowel resection. Quantitative real-time polymerase chain reaction method was used to investigate the copy number variations of NCOA3 as well as gene expression in the collected tissues.
Results:
Copy number gains of NCOA3 were detected in 39 CRC samples (27.5%) and were correlated with tumor progression (χ2 = 6.42, P = 0.0112). Moreover, there was a positive correlation between copy number gain and mRNA over-expression of NCOA3 in CRCs (P = 0.0023). Expression level of NCOA3 mRNA was also enhanced in the CRC samples with unaltered copy numbers (3.85 ± 1.23 vs. 2.71 ± 0.64, P < 0.01).
Conclusion:
Sporadic colorectal cancers exhibit different mechanisms of NCOA3 regulation.
