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A Mouse Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy Procedure Aided by Microscopy
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Hepatoportal sclerosis clinical different evolutionary stages: presentation of 3 cases and literature review

Alejandro Martínez-Caselles1, José Antonio Pons-Miñano, Ángel Vargas-Acosta

  • 1Department of Digestive Diseases, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain. alexmart82@hotmail.com

Revista Espanola De Enfermedades Digestivas
|March 1, 2012
PubMed

Hepatoportal sclerosis (HPS) is characterized by presinusoidal intrahepatic portal hypertension associated with splenomegaly and anemia in patients with non-cirrhotic liver. Liver biopsy is essential, especially to rule out other processes. Being a disease of unknown etiology, the majority of cases have been described in eastern countries. However, it may be an underdiagnosed disease in the West. Symptoms are related to portal hypertension and the clinical spectrum is wide, ranging from anemia with normal liver function tests to bleeding due to esophageal varices. Treatment is directed to the complications and the prognosis is better than in patients with cirrhosis.We report three cases of HPS presenting at different clinical stages and the findings of liver biopsies, the clinical outcomes and a review of scientific literature.

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