Related Experiment Videos
Metastatic Crohn disease: a rare cutaneous entity
1Department of Pathology, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA.
Archives of Pathology & Laboratory Medicine
|March 1, 2012
Summary
Metastatic Crohn disease is a rare skin condition with granulomatous lesions separate from the GI tract. Diagnosis requires integrating clinical, microscopic, and ancillary findings for effective treatment.
Area of Science:
- Dermatology
- Gastroenterology
- Pathology
Background:
- Metastatic Crohn disease (MCD) is a rare cutaneous manifestation of Crohn disease.
- Characterized by noncaseating, granulomatous skin lesions distant from the gastrointestinal tract.
- It presents diagnostic challenges due to its rarity and resemblance to other granulomatous skin conditions.
Purpose of the Study:
- To review the clinical features of metastatic Crohn disease.
- To discuss histopathologic characteristics and suggested pathogenesis.
- To outline the differential diagnosis and current therapeutic options for MCD.
Main Methods:
- Literature review of clinical, histopathologic, and therapeutic data on metastatic Crohn disease.
- Analysis of diagnostic criteria and differential diagnoses.
- Synthesis of information on pathogenesis and treatment strategies.
Main Results:
- MCD presents with unique clinical and histopathologic findings, distinct from other granulomatous dermatoses.
- Age and sex do not appear to significantly influence the occurrence of MCD.
- Accurate diagnosis necessitates a multidisciplinary approach integrating clinical, histological, and diagnostic data.
Conclusions:
- Metastatic Crohn disease is a rare but distinct dermatologic entity.
- Comprehensive evaluation including clinical presentation, histology, and diagnostic studies is crucial for diagnosis.
- Management involves addressing both the cutaneous and underlying gastrointestinal disease.
Related Concept Videos
01:30Inflammatory Bowel Disease II: Crohn's Disease
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
01:25Inflammatory Bowel Disease III: Crohn's Disease
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
01:23Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
01:30Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
01:20Inflammatory Bowel Disease IV: Clinical Manifestations
Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
01:17Chronic Bowel Disorders: Introduction
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...