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Updated: Aug 31, 2025
Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
Treatment failure patterns are similar between p16- and p16+ oropharyngeal squamous cell carcinomas
Chelsea S Hamill1, Richard Grant Muller1, Kate Clancy1
1Department of Otolaryngology-Head and Neck Surgery University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine Cleveland Ohio USA.
Background:
The incidence of p16+ oropharyngeal squamous cell carcinoma (OPSCC) has been increasing. The notion that p16+ OPSCC has a propensity for atypical and disseminating metastasis has gained traction. We compared treatment failure patterns in p16+ and p16- OPSCC and evaluated survival impact.
Methods:
Retrospective analysis of patients with recurrent/metastatic OPSCC disease between 1/2009 and 12/2019.
Results:
Thirty-eight p16+ and 36 p16- patients were identified. Three distinct failure patterns (distant vs. locoregional, atypical vs. typical, and disseminating vs. non-disseminating) were studied. No significant differences were found between p16+ and p16- patients. Multivariate analysis showed p16 status was an independent prognostic biomarker; p16+ patients have a favorable overall survival compared to p16- patients (HR 0.34, 95% CI 0.16-0.77; P = .005).
Conclusions:
We challenge the view that p16+ OPSCC exhibits a distinctive treatment failure pattern and showed that p16 status impacts patient survival independent of disease progression.
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