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Updated: May 24, 2026
Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
Published on: February 19, 2021
Quantification of perfusion and permeability in multiple sclerosis: dynamic contrast-enhanced MRI in 3D at 3T
Michael Ingrisch1, Steven Sourbron, Dominik Morhard
1Josef Lissner Laboratory for Biomedical Imaging, Department of Clinical Radiology, University Hospitals Munich-Grosshadern, Ludwig Maximilian University of Munich, Germany. michael.ingrisch@med.uni-muenchen.de
Background And Purpose:
The quantification of cerebral blood flow (CBF), cerebral blood volume (CBV), and blood-brain barrier permeability in scattered lesions in the brain is a methodological challenge. We aimed to investigate the feasibility of a 3D T1-weighted dynamic contrast-enhanced (DCE) MRI acquisition in combination with a 2-compartment modeling approach for the quantification of CBF, CBV and permeability surface area product (PS) in lesions, and normal-appearing white matter (NAWM) in patients with multiple sclerosis (MS).
Material And Methods:
In all, 19 MS patients (mean age 35 years, 12 female) underwent DCE-MRI with a 3D T1-weighted spoiled gradient-echo sequence on a 3T MRI scanner. A total of 44 slices (thickness 3 mm) with an in-plane resolution of 1.7 × 1.7 mm(2) (matrix size 128 × 104), providing coverage of the whole brain, were acquired every 2.1 seconds over a total measurement time of 420 s. Data postprocessing was performed using a set of 2-compartment models with automated model selection; CBF, CBV, and PS as a measure of blood-brain barrier leakage were determined in contrast-enhancing (CE) and nonenhancing lesions as well as in NAWM.
Results:
Perfusion quantification produced reasonable values in lesions as well as in NAWM. In CE lesions, CBF (22.9 (22.7) vs. 15.8 (6.7) mL/100 mL/min), CBV (1.18 (0.48) vs. 0.76 (0.19) mL/100 mL), and PS (0.98 (0.46) vs. 0.04 (0.03) mL/100 mL/min) were significantly (P < 0.001) higher than in NAWM. In nonenhancing lesions, a weakly (P < 0.05) significantly increased CBV of 1.00 (0.35) mL/100 mL, compared with NAWM, was observed.
Conclusion:
Our study demonstrates the feasibility of 3D T1-weighted DCE-MRI for the quantitative assessment of CBF, CBV, and PS in NAWM as well as in multiple MS lesions scattered throughout the brain, even without previous knowledge of their location. Quantification on the region level produced reasonable values both in lesions and in NAWM, but parameter maps would benefit from an increase in contrast-to-noise ratio. The increased values of CBF, CBV, and PS in CE lesions may reflect inflammatory activity, the heterogeneity of parameter estimates suggests a potential for lesion characterization. NAWM appears hypoperfused, this is in accordance with previous studies, but requires validation with a control group.
Insights
This study shows 3D T1-weighted dynamic contrast-enhanced MRI can quantify blood flow and volume in multiple sclerosis lesions. These findings may help characterize lesion activity and understand brain perfusion changes.
Area of Science:
- Neuroimaging
- Radiology
- Medical Physics
Background:
- Quantifying cerebral blood flow (CBF), cerebral blood volume (CBV), and blood-brain barrier permeability in multiple sclerosis (MS) lesions is challenging.
- Accurate assessment is crucial for understanding disease mechanisms and evaluating treatment efficacy.
Purpose of the Study:
- To investigate the feasibility of 3D T1-weighted dynamic contrast-enhanced (DCE) MRI with 2-compartment modeling.
- To quantify CBF, CBV, and permeability surface area product (PS) in MS lesions and normal-appearing white matter (NAWM).
Main Methods:
- 19 MS patients underwent whole-brain DCE-MRI using a 3T scanner with a 3D T1-weighted sequence.
- Data were acquired every 2.1 seconds for 420 seconds, covering 44 slices.
- 2-compartment modeling was used to determine CBF, CBV, and PS in contrast-enhancing (CE) lesions, nonenhancing lesions, and NAWM.
Main Results:
- Perfusion quantification yielded reasonable values in both lesions and NAWM.
- CE lesions showed significantly higher CBF, CBV, and PS compared to NAWM (P < 0.001).
- Nonenhancing lesions exhibited significantly increased CBV compared to NAWM (P < 0.05).
Conclusions:
- 3D T1-weighted DCE-MRI is feasible for quantitative assessment of CBF, CBV, and PS in MS lesions and NAWM.
- Increased values in CE lesions may indicate inflammatory activity, suggesting potential for lesion characterization.
- NAWM appears hypoperfused, consistent with prior studies, warranting further validation.
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