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Updated: May 24, 2026
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Therapeutic options for advanced prostate cancer: 2011 update
Aurelius Omlin1, Johann S de Bono
1Drug Development Unit, The Institute of Cancer Research, ICR and Royal Marsden NHS Foundation Trust, Sycamore House, Downs Road, Sutton, Surrey, SM25PT, UK.
Current Urology Reports
|March 1, 2012
Summary
Castration-resistant prostate cancer (CRPC) still depends on androgens and responds to treatments like CYP17 inhibition. Recent advancements offer new therapeutic options for advanced prostate cancer patients.
Area of Science:
- Oncology
- Urology
Background:
- Metastatic prostate cancer often progresses to castration-resistant prostate cancer (CRPC) despite initial hormonal therapy.
- CRPC remains a significant clinical challenge, necessitating novel treatment strategies.
Purpose of the Study:
- To review recent developments in the treatment of castration-resistant prostate cancer.
- To highlight novel therapeutic agents and strategies for advanced prostate cancer.
Main Methods:
- Review of recent phase 3 clinical trials and therapeutic advancements in CRPC.
- Analysis of data on novel agents including abiraterone acetate, cabazitaxel, sipuleucel-T, MDV3100, and radium-223.
Main Results:
- Abiraterone acetate demonstrated efficacy by targeting CYP17 inhibition, confirming androgen dependence in CRPC.
- Cabazitaxel, sipuleucel-T, MDV3100, and radium-223 showed overall survival benefits in various patient populations.
- Denosumab proved superior to zoledronic acid in preventing skeletal-related events in metastatic bone disease.
Conclusions:
- CRPC is treatable with agents targeting androgen pathways and other novel mechanisms.
- Recent therapeutic advancements have significantly improved outcomes for patients with advanced prostate cancer.
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