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Published on: June 9, 2023
Primary thyroid lymphomas. A clinicopathological study of 8 cases
R Chetty1, E Bolding, C A Johnson
1Department of Anatomical Pathology, University of Cape Town.
Summary
Primary non-Hodgkin's lymphoma in elderly women treated with surgery, chemotherapy, and radiation showed excellent outcomes. These thyroid lymphomas are part of the mucosa-associated lymphoma spectrum, suggesting a favorable prognosis.
Area of Science:
- Oncology
- Pathology
- Immunology
Background:
- Primary non-Hodgkin's lymphoma can affect the thyroid gland.
- Thyroid lymphomas are rare and their clinical presentation can vary.
- Mucosa-associated lymphomas often have a better prognosis than nodal lymphomas.
Purpose of the Study:
- To report the treatment outcomes of elderly women with primary thyroid non-Hodgkin's lymphoma.
- To describe the clinical and histological features of these thyroid lymphomas.
- To discuss the classification and prognosis of thyroid lymphomas within the context of mucosa-associated lymphomas.
Main Methods:
- Retrospective analysis of eight elderly women with primary thyroid non-Hodgkin's lymphoma.
- Treatment involved a combination of surgery, chemotherapy, and radiation therapy.
- Histopathological examination including light-chain restriction analysis.
Main Results:
- All eight patients achieved an excellent outcome with the combined treatment modality.
- Patients presented with thyromegaly, without lymphadenopathy or hepatosplenomegaly.
- Histology revealed diffuse follicle-centre cell-like tumors with extrathyroidal extension and lymphoepithelial lesions; monoclonality was observed in 5 patients.
Conclusions:
- Primary thyroid non-Hodgkin's lymphoma in elderly women can be effectively treated with a multimodal approach.
- Thyroid lymphomas share characteristics with mucosa-associated lymphomas, indicating a potentially favorable prognosis compared to nodal lymphomas.
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