Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PARP inhibition modulates mitochondrial morphology and metabolism under hypoxic stress in cancer cells.

Cell death & disease·2026
Same author

Targeting MARylation and DePARylation in Cancer Therapy: New Promising Therapeutic Opportunities.

Cancers·2025
Same author

Tuning lipid nanocarrier mechanical properties to improve glioblastoma targeting and blood brain barrier penetration.

Nanoscale·2025
Same author

Maternal immune activation imprints translational dysregulation and differential MAP2 phosphorylation in descendant neural stem cells.

Molecular psychiatry·2025
Same author

Microglial Phagocytosis During Embryonic and Postnatal Development.

Advances in neurobiology·2024
Same author

Maternal Immune Activation imprints translational dysregulation and differential MAP2 phosphorylation in descendant neural stem cells.

bioRxiv : the preprint server for biology·2024

Related Experiment Video

Updated: May 24, 2026

Modeling Neuronal Death and Degeneration in Mouse Primary Cerebellar Granule Neurons
10:36

Modeling Neuronal Death and Degeneration in Mouse Primary Cerebellar Granule Neurons

Published on: November 6, 2017

Microglia and neuronal cell death.

José L Marín-Teva1, Miguel A Cuadros, David Martín-Oliva

  • 1Departamento de Biología Celular, Facultad de Ciencias, Universidad de Granada, Granada, Spain. jlmarin@ugr.es

Neuron Glia Biology
|March 2, 2012
PubMed
Summary
This summary is machine-generated.

Microglia, the brain's immune cells, play dual roles in neuronal survival and death during development and adulthood. Their complex functions are crucial for central nervous system health, with disruptions leading to adverse outcomes.

More Related Videos

In vitro Quantitative Imaging Assay for Phagocytosis of Dead Neuroblastoma Cells by iPSC-Macrophages
09:48

In vitro Quantitative Imaging Assay for Phagocytosis of Dead Neuroblastoma Cells by iPSC-Macrophages

Published on: February 14, 2021

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
09:12

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

Related Experiment Videos

Last Updated: May 24, 2026

Modeling Neuronal Death and Degeneration in Mouse Primary Cerebellar Granule Neurons
10:36

Modeling Neuronal Death and Degeneration in Mouse Primary Cerebellar Granule Neurons

Published on: November 6, 2017

In vitro Quantitative Imaging Assay for Phagocytosis of Dead Neuroblastoma Cells by iPSC-Macrophages
09:48

In vitro Quantitative Imaging Assay for Phagocytosis of Dead Neuroblastoma Cells by iPSC-Macrophages

Published on: February 14, 2021

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
09:12

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

Area of Science:

  • Neuroscience
  • Immunology
  • Developmental Biology

Background:

  • Microglia are the central nervous system's (CNS) resident immune cells, originating from the mesoderm.
  • During development, undifferentiated (ameboid) microglia migrate, proliferate, and phagocytose cells, influencing neuronal populations.
  • Mature microglia in the adult CNS exhibit dynamic processes, impacting neuronal survival and elimination.

Purpose of the Study:

  • To review the multifaceted relationship between microglia and neuronal death/survival.
  • To explore microglial roles during both normal CNS development and in response to injury in adulthood.

Main Methods:

  • Literature review of studies on microglial function and neuronal interactions.
  • Analysis of microglial roles in neurodevelopment and adult neuroinflammation.

Main Results:

  • Microglia exhibit both neuroprotective and neurotoxic effects.
  • Aberrant microglial activation or dysfunction can negatively impact CNS organization and function.

Conclusions:

  • Microglial cell behavior is critical for maintaining nervous tissue homeostasis.
  • Understanding microglial dynamics is essential for addressing CNS disorders.