Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Integration of Synaptic Events

Integration of Synaptic Events

Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...

Electrical Synapses

Electrical Synapses

Electrical synapses found in all nervous systems play important and unique roles. In these synapses, the presynaptic and postsynaptic membranes are very close together (3.5 nm) and are actually physically connected by channel proteins forming gap junctions.
Gap junctions allow the current to pass directly from one cell to the next. In contrast, in the chemical synapse, the neurotransmitters carry the information through the synaptic cleft from one neuron to the next. They consist of two...

Postsynaptic Potential (PSP)

Postsynaptic Potential (PSP)

Postsynaptic potential (PSP) refers to a change in the electrical potential of a neuron when neurotransmitters released by presynaptic neurons bind to postsynaptic receptors. This potential can either be excitatory, leading to depolarization and ultimately action potential generation, or inhibitory, leading to hyperpolarization and suppression of the postsynaptic neuron.
There are two types of receptors: ionotropic and metabotropic.
The ionotropic receptor is the membrane protein that has an...

The Synapse

The Synapse

Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.

Synaptic Signaling

Synaptic Signaling

Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...

Synaptic Signaling

Synaptic Signaling

Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Peptide Synthesis Nomenclature.

Journal of peptide science : an official publication of the European Peptide Society·2025

Same author

Detecting depression in speech using verbal behavior analysis: a cross-cultural study.

Frontiers in psychology·2025

Same author

A Novel Pipeline for Adrenal Gland Segmentation: Integration of a Hybrid Post-Processing Technique with Deep Learning.

Journal of imaging informatics in medicine·2025

Same author

CRP and sCD25 help distinguish between adult-onset Still's disease and HLH.

European journal of haematology·2024

Same author

Mathematical Modeling of PI3K/Akt Pathway in Microglia.

Neural computation·2024

Same author

The influence of astrocytic leaflet motility on ionic signalling and homeostasis at active synapses.

Scientific reports·2023

Search research articles

Related Experiment Video

Updated: May 24, 2026

A Simple Stimulatory Device for Evoking Point-like Tactile Stimuli: A Searchlight for LFP to Spike Transitions

A Simple Stimulatory Device for Evoking Point-like Tactile Stimuli: A Searchlight for LFP to Spike Transitions

Published on: March 25, 2014

Synchrony: a spiking-based mechanism for processing sensory stimuli.

Cornelius Glackin¹, Liam Maguire, Liam McDaid

¹Adaptive Systems Research Group, School of Computer Science, University of Hertfordshire, College Lane, Hatfield, Hertfordshire, AL10 9AB, United Kingdom. c.glackin2@herts.ac.uk

Neural Networks : the Official Journal of the International Neural Network Society

|March 2, 2012

Summary

This study explores how near-synchronous neural firing, inspired by the cochlear nucleus, can improve auditory processing. Experiments with leaky integrate and fire neurons show this synchrony reduces noise and enhances spectral contrast in stimuli.

More Related Videos

Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments

Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments

Published on: November 12, 2019

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Published on: April 22, 2015

Related Experiment Videos

Last Updated: May 24, 2026

A Simple Stimulatory Device for Evoking Point-like Tactile Stimuli: A Searchlight for LFP to Spike Transitions

A Simple Stimulatory Device for Evoking Point-like Tactile Stimuli: A Searchlight for LFP to Spike Transitions

Published on: March 25, 2014

Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments

Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments

Published on: November 12, 2019

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Published on: April 22, 2015

Area of Science:

Computational neuroscience
Neural coding

Background:

Neuronal synchrony has dual roles: beneficial for brain coordination and detrimental in conditions like epilepsy.
Understanding synchrony's impact is crucial for deciphering neural communication.

Purpose of the Study:

To investigate how near-synchronous states in leaky integrate and fire (LIF) neurons can process sensory stimuli.
To explore the potential of neural synchrony for noise reduction and spectral enhancement in auditory processing.

Main Methods:

Simulated leaky integrate and fire (LIF) neurons with lateral inhibitory connectivity.
Investigated neuron topology inspired by the cochlear nucleus.
Introduced connection length and neighborhood radius parameters to control connectivity.
Utilized information-theoretic principles to quantify information retention.

Main Results:

Near-synchronous states in LIF neurons were generated using specific connectivity parameters.
Demonstrated the ability of these configurations to reduce noisy spikes in auditory stimuli.
Showed an increase in the spectral contrast of processed auditory stimuli.

Conclusions:

Harnessing near-synchronous neural activity offers a promising mechanism for enhancing sensory information processing.
The proposed model provides a framework for understanding how neural network topology influences coding efficiency.
This approach has implications for developing bio-inspired signal processing techniques.