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Updated: May 24, 2026

Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes
Published on: June 28, 2024
Maternal risk for Down syndrome is modulated by genes involved in folate metabolism
Bruna Lancia Zampieri1, Joice Matos Biselli, Eny Maria Goloni-Bertollo
1Unidade de Pesquisa em Genética e Biologia Molecular (UPGEM), São José do Rio Preto, São Paulo, Brazil.
Abstract:
Studies have shown that the maternal risk for Down syndrome (DS) may be modulated by alterations in folate metabolism. The aim of this study was to evaluate the influence of 12 genetic polymorphisms involved in folate metabolism on maternal risk for DS. In addition, we evaluated the impact of these polymorphisms on serum folate and plasma methylmalonic acid (MMA, an indicator of vitamin B
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