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Published on: February 25, 2016
Nitro-oxidative stress biomarkers in active and inactive men
L Bjork1, N T Jenkins, S Witkowski
1University of Maryland, Department of Kinesiology, College Park 20742-2611, USA.
International Journal of Sports Medicine
|March 2, 2012
Summary
A sedentary lifestyle may increase oxidized LDL (ox-LDL) levels, a marker of oxidative stress. Oxidative stress markers correlate with cardiovascular disease risk factors, highlighting the impact of inactivity on heart health.
Area of Science:
- Cardiovascular Science
- Exercise Physiology
- Biochemistry
Background:
- Oxidative stress markers are emerging indicators of cardiovascular disease (CVD) risk.
- Understanding the influence of exercise and aging on these markers is crucial for CVD prevention.
Purpose of the Study:
- To investigate the effects of long-term exercise and age on oxidative stress biomarkers: plasma oxidized LDL (ox-LDL), nitrotyrosine, and myeloperoxidase (MPO).
- To assess the association of these oxidative stress markers with plasma nitric oxide (NOx) levels and conventional CVD risk factors.
Main Methods:
- Comparison of young and older active and inactive men, matched for age and BMI.
- Measurement of plasma levels of ox-LDL, nitrotyrosine, MPO, and NOx.
- Correlation analysis with lipoprotein-lipid levels and Framingham risk score.
Main Results:
- Younger subjects exhibited lower plasma nitrotyrosine levels compared to older subjects.
- Young inactive men showed higher ox-LDL levels than both young and older active men.
- Oxidative stress markers, especially ox-LDL, correlated with conventional CVD risk factors and Framingham risk score in older men.
Conclusions:
- A sedentary lifestyle is linked to elevated ox-LDL levels.
- Oxidative stress markers are associated with other CVD risk factors and overall CVD risk.
- No relationship was found between oxidative stress markers and nitric oxide bioavailability.
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