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Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...

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Related Experiment Video

Updated: May 24, 2026

Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation
09:13

Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation

Published on: April 6, 2017

Platelet concentrates: past, present and future.

Shobha Prakash, Aditi Thakur

    Journal of Maxillofacial and Oral Surgery
    |March 2, 2012
    PubMed
    Summary

    Platelet concentrates, including platelet-rich plasma and platelet-rich fibrin, are vital for healing in oral surgery. This review traces their development from early fibrin sealants.

    Area of Science:

    • Biomedical Engineering
    • Regenerative Medicine
    • Oral and Maxillofacial Surgery

    Background:

    • Platelets are essential for hemostasis and wound healing.
    • Platelet growth factors act as key healing cytokines.
    • Autologous platelet concentrates are increasingly used in oral and maxillofacial surgery.

    Purpose of the Study:

    • To review the evolution of platelet concentrates.
    • To describe the development of first and second-generation platelet concentrates.
    • To contextualize platelet-rich plasma and platelet-rich fibrin within their historical development from fibrin sealants.

    Main Methods:

    • Literature review of scientific publications.
    • Historical analysis of platelet concentrate development.
    Keywords:
    Fibrin sealantsPlatelet growth factorsPlatelet rich fibrinPlatelet rich plasmaWound healing

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    A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
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    A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

    Published on: February 14, 2017

    Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
    10:25

    Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

    Published on: March 19, 2016

    Related Experiment Videos

    Last Updated: May 24, 2026

    Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation
    09:13

    Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation

    Published on: April 6, 2017

    A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
    09:38

    A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

    Published on: February 14, 2017

    Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
    10:25

    Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

    Published on: March 19, 2016

  • Comparative analysis of early and later generation platelet concentrates.

    • Main Results:

    • Fibrin sealants represent the precursor to modern platelet concentrates.
    • Platelet-rich plasma (PRP) emerged as the first generation.
    • Platelet-rich fibrin (PRF) represents the second generation, offering distinct properties.

    Conclusions:

    • The evolution from fibrin sealants to PRP and PRF demonstrates significant advancements in regenerative therapies.
    • Understanding this progression is crucial for optimizing the application of platelet concentrates in surgical practice.
    • Continued innovation in platelet concentrate technology holds promise for enhanced patient outcomes.