Related Experiment Video

Updated: May 24, 2026

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

[Myocardial morphological changes in atrial fibrillation]

L B Mitrofanova, G B Koval'skiĭ

    Arkhiv Patologii
    |March 3, 2012
    PubMed

    Insights

    Viral infections like enterovirus and parvovirus B19 may cause chronic myocarditis, leading to fibrosis and amyloidosis in patients with ischemic heart disease and atrial fibrillation.

    Area of Science:

    • Cardiology
    • Pathology
    • Virology

    Context:

    • Investigated hearts from 21 deceased patients with ischemic heart disease (IHD).
    • Examined atrial appendages from 66 patients with heart diseases and IHD.
    • Utilized histological, morphometrical, semiquantitative, and immunohistochemical methods.

    Purpose:

    • To determine the potential link between viral infections, myocarditis, and atrial fibrillation (AF) in patients with IHD.
    • To identify specific viral antigens and pathological changes in myocardial tissue associated with AF.

    Summary:

    • Chronic myocarditis, potentially caused by viral infections (enterovirus, parvovirus B19, adenovirus), was evident in patients with AF.
    • Myocardial fibrosis, adiposis, and abundant diffuse amyloidosis were observed in patients with AF.
    • Patients with paroxysmal AF showed a higher degree of fibrosis compared to those with stable AF.

    Impact:

    • This research highlights the role of viral-induced myocarditis and subsequent pathological changes in the development of AF in IHD patients.
    • Findings suggest potential targets for therapeutic interventions aimed at preventing or managing AF in this patient population.

    More Related Videos

    Assessment of Cardiac Morphological and Functional Changes in Mouse Model of Transverse Aortic Constriction by Echocardiographic Imaging09:05

    Assessment of Cardiac Morphological and Functional Changes in Mouse Model of Transverse Aortic Constriction by Echocardiographic Imaging

    Published on: June 21, 2016

    Related Concept Videos

    ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias01:25

    ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias

    Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
    Myocarditis I: Introduction01:21

    Myocarditis I: Introduction

    Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
    Heart Failure II: Pathophysiology01:29

    Heart Failure II: Pathophysiology

    Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
    Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

    Mitral Stenosis II: Clinical features and Diagnostic Tests

    Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
    Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

    Cardiomyopathy III: Hypertrophic Cardiomyopathy

    Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...