Related Experiment Video

Updated: May 24, 2026

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

Cardiovascular disease in patients with end-stage renal disease on hemodialysis in a developing country

Leila S V Silva1, Rodrigo A Oliveira, Geraldo B Silva

  • 1School of Medicine, Federal University of Ceara, Fortaleza, CE, Brazil.

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia
|March 3, 2012
PubMed

Insights

Cardiovascular disease is a major concern for patients with end-stage renal disease (ESRD). This study identified hypertension and dyslipidemia as key risk factors and prevalent conditions like left ventricular hypertrophy in Brazilian ESRD patients undergoing hemodialysis.

Area of Science:

  • Nephrology
  • Cardiology
  • Public Health

Background:

  • Cardiovascular disease (CVD) is the leading cause of mortality in patients with end-stage renal disease (ESRD).
  • Understanding prevalent CVDs and their risk factors in ESRD populations is crucial for improving patient outcomes.
  • Hemodialysis (HD) patients represent a significant subgroup of ESRD patients with high cardiovascular risk.

Purpose of the Study:

  • To identify the primary cardiovascular diseases and associated risk factors in patients with ESRD undergoing hemodialysis in Brazil.
  • To investigate the specific prevalence of conditions such as left ventricular hypertrophy, atherosclerotic disease, valvular disease, and coronary artery disease.
  • To determine the significant risk factors contributing to these cardiovascular conditions in the studied population.

Main Methods:

  • A cross-sectional study was conducted involving 160 patients with ESRD on hemodialysis in Brazil.
  • Data collection included patient demographics, medical history, and clinical parameters.
  • Statistical analyses were performed to identify associations between risk factors and cardiovascular diseases.

Main Results:

  • The most prevalent cardiovascular diseases were left ventricular hypertrophy, atherosclerotic disease, valvular disease, and coronary artery disease.
  • Key risk factors identified include arterial hypertension (89.4%), dyslipidemia (78.3%), low high-density lipoprotein levels (84.2%), and low physical activity (64.1%).
  • Significant associations were found between specific risk factors and cardiovascular conditions, including family history, high LDL, sedentary lifestyle, diabetes mellitus, secondary hyperparathyroidism, hyperglycemia, hypercalcemia, and race.

Conclusions:

  • Hypertension and dyslipidemia are common and significant risk factors for cardiovascular diseases in ESRD patients on hemodialysis.
  • Left ventricular hypertrophy, atherosclerotic disease, valvular disease, and coronary artery disease are prevalent in this population.
  • Targeting modifiable risk factors like hypertension, dyslipidemia, and lifestyle changes is essential for managing cardiovascular risk in ESRD patients.

More Related Videos

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Related Concept Videos

Dialysis01:27

Dialysis

Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Dialysis01:15

Dialysis

Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Hemodialysis I: Introduction01:25

Hemodialysis I: Introduction

Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...