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Updated: Nov 15, 2025
A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
COVID-19 in a temporal relation to the onset of multiple sclerosis
Yara D Fragoso1, Filippe A S Pacheco2, Guilherme L Silveira3
1Professor of the Postgraduate Program for Health and Environment, Universidade Metropolitana de Santos, Santos, SP, Brazil; MS & Headache Research, Santos, SP, Brazil.
Abstract:
Neurological complications of COVID-19 have been described. We present the case of a 27-year-old woman who developed COVID-19 in April 2020. She continued to present anosmia and ageusia eight months later. Six months after contracting COVID-19, she developed dysesthesia, hypoesthesia and hyperreflexia. Her magnetic resonance imaging showed demyelinating lesions, of which two were enhanced by gadolinium. She was positive for oligoclonal bands in her spinal fluid. This patient developed multiple sclerosis with a temporal relationship to COVID-19. We believe that SARS-CoV-2 led to her autoimmune disease through a virus-induced neuroimmunopathological condition.
