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Abdominal abscess due to NDM-1-producing Klebsiella pneumoniae in Spain

Jesús Oteo1,2, Diego Domingo-García3, Sara Fernández-Romero2

  • 1Spanish Network in Infectious Pathology (REIPI), Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.

Journal of Medical Microbiology
|March 3, 2012
PubMed

Insights

A Spanish patient developed an abdominal abscess caused by New Delhi metallo-beta-lactamase (NDM-1) producing Klebsiella pneumoniae after treatment in India. The patient recovered following abscess drainage.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Genetics

Background:

  • The emergence of carbapenem-resistant Enterobacteriaceae (CRE) poses a significant global health threat.
  • Klebsiella pneumoniae is a common cause of healthcare-associated infections and exhibits increasing antimicrobial resistance.

Observation:

  • A 35-year-old Spanish patient presented with an abdominal abscess following hospitalization in India for perforated appendicitis and peritonitis.
  • The causative agent was identified as Klebsiella pneumoniae harboring the New Delhi metallo-beta-lactamase (NDM-1) gene.

Findings:

  • The NDM-1 producing Klebsiella pneumoniae strain belonged to MLST type 231.
  • The isolate possessed multiple antibiotic resistance genes, including bla(CTX-M-15), armA methylase, aac(6')-Ib-cr, dfrA12, and qnrB.
  • Notably, the strain lacked porin genes ompK35 and ompK36, which may contribute to its resistance profile.

Implications:

  • This case highlights the international spread of NDM-1 producing Klebsiella pneumoniae.
  • Understanding the genetic basis of resistance in such strains is crucial for effective treatment strategies.
  • Prompt diagnosis and source control, such as abscess drainage, are vital for patient outcomes.

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