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Related Concept Videos

Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
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Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
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Cell-mediated Immune Responses

Overview
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

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Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
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Natural killer cell tolerance: control by self or self-control?

Baptiste N Jaeger1, Eric Vivier

  • 1Centre d'Immunologie de Marseille-Luminy, Université de la Méditerranée, Marseille, France. bjaeger@ciml.univ-mrs.fr

Cold Spring Harbor Perspectives in Biology
|March 3, 2012
PubMed
Summary
This summary is machine-generated.

The immune system must distinguish self from non-self to prevent autoimmune diseases. This review explores natural killer (NK) cell tolerance mechanisms, crucial for innate immunity and preventing self-attack.

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Area of Science:

  • Immunology
  • Cellular Biology

Background:

  • The immune system faces the challenge of eliminating pathogens and abnormal cells while tolerating healthy self-cells.
  • Failure in self-tolerance can lead to autoimmune diseases like lupus, psoriasis, and type I diabetes.
  • Mechanisms ensuring tolerance in the innate immune system, particularly natural killer (NK) cells, are not fully understood.

Purpose of the Study:

  • To review current knowledge on natural killer (NK) cell tolerance.
  • To understand how NK cells differentiate between self and non-self or altered-self cells.
  • To elucidate the mechanisms preventing NK cell autoreactivity.

Main Methods:

  • Literature review of existing research on NK cell function and tolerance.
  • Analysis of studies investigating NK cell recognition and effector functions.
  • Synthesis of data on mechanisms underlying NK cell self-tolerance.

Main Results:

  • NK cells are innate immune lymphocytes capable of killing targets and producing cytokines without prior sensitization.
  • Tolerance mechanisms are essential to prevent NK cells from attacking healthy host cells.
  • Understanding NK cell tolerance is key to preventing autoimmune responses.

Conclusions:

  • NK cell tolerance is a critical aspect of innate immunity.
  • Further research is needed to fully elucidate the mechanisms of NK cell self-tolerance.
  • Knowledge of NK cell tolerance may offer insights into autoimmune disease pathogenesis.