Dermal toxicity to rats of isoproturon technical and formulation

Information on the toxicity of urea-based herbicides is meagre and no data are available on the subacute dermal toxicity of isoproturon and its formulation. Repeated applications of isoproturon technical (IPT) and its wettable powder formulation (IPF) to the skin of male and female rats for 21 days caused mild to moderate toxic effects. IPT was more toxic to male rats as evidenced by animal mortality and enzymatic and hematological changes. The toxicity of IPF was less to both sexes. No dose response relationship could be established since the enzymatic and hematological changes produced by 3 different dose levels were equal.