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Related Experiment Video

Updated: May 24, 2026

Lethality Bioassay Using Artemia salina L.

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Published on: October 11, 2022

[Lethal poisoning with the death-cap mushrooms].

S A Povzun, V V Shilov, E N Grin'

Sudebno-Meditsinskaia Ekspertiza

|March 6, 2012

Summary

This study examined lethal Death Cap poisoning, revealing severe liver damage (hepatopathy, necrosis) and kidney damage (nephropathy). High bilirubin and low prothrombin/fibrin levels indicate a poor prognosis for amatoxin intoxication.

Area of Science:

Toxicology
Pathology
Clinical Medicine

Background:

The Death Cap mushroom (Amanita phalloides) contains amatoxins, potent toxins causing severe liver and kidney damage.
Understanding the pathological and clinical features of fatal amatoxin poisoning is crucial for diagnosis and treatment.

Purpose of the Study:

To analyze the morphological, clinical, and laboratory findings in fatal Death Cap poisoning.
To compare these findings with those of survived cases to identify prognostic indicators.

Main Methods:

Autopsy analysis of five lethal poisoning cases.
Comparison of clinical and laboratory data from fatal cases with 15 survived cases.

Main Results:

Fatal poisoning was characterized by significant hepatopathy, extensive hepatic necrosis, and nephropathy.

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Elevated blood bilirubin levels were observed in lethal cases.

Lowered prothrombin and fibrin concentrations were associated with unfavorable outcomes.

Conclusions:

Morphological changes, particularly severe liver and kidney damage, are hallmarks of lethal amatoxin poisoning.
Biochemical markers such as elevated bilirubin and decreased prothrombin/fibrin levels are critical indicators of prognosis in Death Cap intoxication.