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Related Concept Videos

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Classification of Epithelial Tissues: Glandular Epithelium

The glandular epithelium is made of one or more epithelial cells modified to synthesize and secrete chemical substances. Glandular epithelia can be classified based on cell number. Unicellular glands have individual secretory cells scattered across the epithelial monolayer. In contrast, multicellular glands consist of a hollow tubular duct attached to the cluster of secretory cells located in the deep pockets.
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[Breast granular cell tumor].

S A Povzun1, N Yu Novitskaya1

  • 1I.I. Dzanelidze St. Petersburg Scientific Research Institute of Emergency Care, St. Petersburg, Russia.

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|July 29, 2024
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Summary

This report details a rare granular cell tumor in the breast, a neoplasm of neuroectodermal origin. Key diagnostic markers include protein S-100 expression and absence of epithelial antigens, distinguishing it from cancer.

Keywords:
breastgranular cell tumormicroscopic differential diagnosis

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Area of Science:

  • Oncology
  • Pathology
  • Radiology

Background:

  • Granular cell tumors (GCTs) are rare neoplasms.
  • GCTs are typically of neuroectodermal origin.
  • Breast localization of GCT is exceptionally uncommon.

Purpose of the Study:

  • To report a case of granular cell tumor in the breast.
  • To outline the differential diagnostic criteria for breast GCT.
  • To highlight imaging characteristics of breast GCT.

Main Methods:

  • Biopsy and histopathological examination.
  • Immunohistochemical analysis for protein S-100, epithelial antigens, histiocytic antigens, oncoproteins, estrogen, and progesterone receptors.
  • Periodic acid-Schiff (PAS) staining.
  • Review of ultrasound and mammography findings.

Main Results:

  • Biopsy confirmed granular cell tumor.
  • Positive cytoplasmic protein S-100 expression.
  • Absence of epithelial and histiocytic antigens, oncoproteins, estrogen, and progesterone receptors.
  • Intracellular granules showed a PAS-positive reaction.
  • Imaging (ultrasound, mammography) initially suggested malignancy or calcification.

Conclusions:

  • Granular cell tumor is a rare breast neoplasm of neuroectodermal origin.
  • Specific immunohistochemical markers are crucial for accurate diagnosis.
  • Radiological findings can mimic breast cancer, necessitating careful histopathological evaluation.