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Synthesis and preliminary antihyperlipidaemic activities evaluation of andrographolide derivatives
Bin Wang1, Chunlei Tang, Yaodan Han
1School of Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
Abstract:
Recent studies indicated that andrographolide was a potential antihyperlipidaemic therapeutic agent. In the paper, the synthesis of a series of andrographolide derivatives was described and their antihyperlipidaemic activities were evaluated in vivo. As compared with TG, TC, HDL-C and LDL-C concentrations, some of the derivatives exhibited better antihyperlipidaemic effects than positive control atromide. Therein, compound 6i, which was the most potent compound, could serve as a new lead for further development of antihyperlipidaemic agents.
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