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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview

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Related Experiment Video

Updated: May 24, 2026

Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation
07:52

Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation

Published on: July 23, 2012

Antigen-specific effector CD8 T cells regulate allergic responses via IFN-γ and dendritic cell function.

Yafang Tang1, Shou Ping Guan, Benson Y L Chua

  • 1Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

The Journal of Allergy and Clinical Immunology
|March 6, 2012
PubMed
Summary

Interferon-gamma (IFN-γ) producing CD8 T cells can prevent allergic lung inflammation. Without IFN-γ, CD8 T cells worsen allergic responses, highlighting IFN-γ

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Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
09:51

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

Related Experiment Videos

Last Updated: May 24, 2026

Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation
07:52

Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation

Published on: July 23, 2012

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
09:51

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

Area of Science:

  • Immunology
  • Allergy Research
  • T cell biology

Background:

  • CD8 T cells play a dual role in allergic responses, capable of both prevention and exacerbation.
  • The precise mechanisms governing the pro- or anti-allergic functions of CD8 T cells remain unclear.

Purpose of the Study:

  • To investigate how CD8 T cells with varying levels of IFN-γ expression influence allergic inflammation.
  • To elucidate the underlying immunological mechanisms by which CD8 T cells modulate allergic responses.

Main Methods:

  • Transfer of effector CD8 T cells from wild-type OT-I and IFN-γ knockout (IFN-γ(-/-)) OT-I mice into ovalbumin (OVA)-sensitized recipient mice.
  • Subsequent challenges with OVA to elicit allergic inflammation.
  • Ex vivo analysis of lung dendritic cells (DCs) and their interaction with CD4 T cells.

Main Results:

  • IFN-γ-producing CD8 T cells (OT-I) attenuated allergic lung eosinophilia and mucus production in an antigen-specific manner.
  • CD8 T cells lacking IFN-γ (IFN-γ(-/-)OT-I) exhibited a Tc2/Tc17 phenotype, reduced cytotoxicity, and exacerbated both eosinophilia and neutrophilia.
  • OT-I CD8 T cells enhanced the capacity of lung DCs to promote T helper 1 (T(H)1) differentiation and boost IFN-γ production by antigen-experienced CD4 T cells.

Conclusions:

  • Effector CD8 T cells can mitigate pulmonary allergic inflammation by promoting a T(H)1 polarization of T cells via dendritic cell modulation.
  • The absence of IFN-γ in CD8 T cells leads to a Tc2/Tc17-biased phenotype, resulting in potentiation of allergic inflammation.