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Photodynamic therapy for choroidal metastasis in 8 cases
Swathi Kaliki1, Carol L Shields, Saad A Al-Dahmash
1Ocular Oncology Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
Ophthalmology
|March 6, 2012
Summary
Photodynamic therapy (PDT) effectively treated choroidal metastasis in 78% of cases, resolving subretinal fluid and reducing tumor thickness. This offers a promising alternative treatment for ocular tumors.
Area of Science:
- Ophthalmology
- Oncology
- Medical Physics
Background:
- Choroidal metastasis presents a significant challenge in ocular oncology.
- Limited treatment options exist for choroidal metastases, necessitating exploration of novel therapeutic approaches.
Purpose of the Study:
- To evaluate the efficacy of photodynamic therapy (PDT) as a treatment for choroidal metastasis.
- To assess tumor control and visual acuity outcomes following PDT.
Main Methods:
- A retrospective, interventional case series involving 8 patients with 9 choroidal tumors.
- Photodynamic therapy administered using verteporfin and a diode laser (689 nm).
- Tumor response, including basal diameter, thickness, and subretinal fluid resolution, was assessed.
Main Results:
- Photodynamic therapy achieved complete tumor control and subretinal fluid resolution in 78% of treated choroidal metastases.
- A mean tumor thickness reduction of 39% was observed post-treatment.
- Vision improved or stabilized in 7 out of 8 eyes, with one instance of intraretinal hemorrhage.
Conclusions:
- Photodynamic therapy demonstrates significant efficacy in managing choroidal metastasis.
- PDT serves as a viable alternative treatment option for patients with choroidal tumors, potentially preserving vision.
