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Related Concept Videos

Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Antiasthma Drugs: β2-Adrenoceptor Agonists01:25

Antiasthma Drugs: β2-Adrenoceptor Agonists

Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce relaxation in these...

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Related Experiment Video

Updated: May 24, 2026

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Asthma outcomes: biomarkers.

Stanley J Szefler1, Sally Wenzel, Robert Brown

  • 1National Jewish Health, Denver, Colorado, USA.

The Journal of Allergy and Clinical Immunology
|March 6, 2012
PubMed
Summary
This summary is machine-generated.

Standardized asthma biomarkers are crucial for clinical research. Multiallergen screening is recommended as a core outcome, with other measures classified as supplemental or emerging.

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Methodology for Sputum Induction and Laboratory Processing
13:28

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

Related Experiment Videos

Last Updated: May 24, 2026

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Methodology for Sputum Induction and Laboratory Processing
13:28

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

Area of Science:

  • Pulmonary Medicine
  • Biomarker Discovery
  • Clinical Research

Background:

  • Biomarker measurement is integral to asthma research for population characterization and understanding environmental/therapeutic effects.
  • Standardized asthma outcome measures are needed for future clinical studies.

Purpose of the Study:

  • To propose standardized biomarkers for asthma clinical research.
  • To classify identified biomarkers into core, supplemental, and emerging categories.

Main Methods:

  • Comprehensive literature search for asthma biomarker studies.
  • Classification of biomarkers based on relevance and need for standardization.
  • Expert group discussion and finalization of recommendations.

Main Results:

  • Multiallergen screening for atopy is the sole recommended core asthma outcome.
  • Complete blood counts, fractional exhaled nitric oxide (Feno), sputum eosinophils, urinary leukotrienes, and IgE are supplemental measures.
  • Sputum polymorphonuclear leukocytes, cortisol, airway imaging, breath markers, and system-wide studies are emerging measures.

Conclusions:

  • Multiallergen screening should be utilized in all asthma trials to define atopic status.
  • Standardized procedures for collecting and storing blood, sputum, and urine specimens in biobanks are recommended.