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Determination of High-affinity Antibody-antigen Binding Kinetics Using Four Biosensor Platforms
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Recent trends in antibody based sensors

Timothy R J Holford1, Frank Davis, Séamus P J Higson

  • 1Cranfield Health, Cranfield University, Cranfield, Bedfordshire, UK.

Biosensors & Bioelectronics
|March 6, 2012
PubMed

This review details recent advances in the fields of immunosensors and closely related immunoassays in the past decade, together with a discussion of possible future trends. Immunosensors can be classified by the way in which they transduce the signal produced upon the formation of an antibody antigen complex. Recent advancements to these methods of detection and transduction are discussed in detail, with particular focus on electrochemical, optical, piezoelectric and magnetic based sensors. The varying applications of these sensors are also discussed. Some of the most significant advances include development of immunosensors for the continuous monitoring of analytes, point of care (PoC) devices, with lower unit costs, automation, reusability and ease of use. Immunosensor technology has advanced at a prolific rate since its conception and has grown into a diverse area of ongoing research.

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