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Formulation and optimization of sustained release Stavudine microspheres using response surface methodology.
Sanjay Dey1, Soumen Pramanik, Ananya Malgope
1Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam 786004, India.
ISRN Pharmaceutics
|March 6, 2012
Summary
This study optimized microsphere formulations for sustained drug release. The best formulation achieved 70% encapsulation efficiency and released drugs over 12 hours.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Microspheres are crucial for controlled drug release.
- Optimization is needed to enhance drug encapsulation and release profiles.
Purpose of the Study:
- To formulate and optimize microsphere drug delivery systems.
- To evaluate the impact of polymer-drug ratio and stirring speed on microsphere performance.
Main Methods:
- A 3(2) full factorial design was utilized.
- Independent variables included polymer-to-drug ratio and stirring speed.
- Dependent variables were encapsulation efficiency, particle size, and drug release time.
Main Results:
- The optimal formulation showed 70% encapsulation efficiency.
- Mean particle size was 290 μm.
- Sustained drug release exceeded 12 hours.
Conclusions:
- The study successfully identified an optimized microsphere formulation.
- The optimized formulation demonstrated excellent sustained drug release characteristics.
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