Related Experiment Video
Updated: Apr 28, 2026
05:44
Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
2.4K
Formulation development and optimization of fast dissolving tablets of aceclofenac using natural superdisintegrant
Lovleen Kaur1, Rajni Bala1, Neha Kanojia1
1Chitkara College of Pharmacy, Chandigarh-Patiala National Highway, Rajpura, Patiala, Punjab 140401, India.
ISRN Pharmaceutics
|June 20, 2014
Summary
This study developed fast-dissolving Aceclofenac tablets using Lepidium sativum mucilage as a natural superdisintegrant. The optimized formulation showed rapid disintegration and complete drug release within 15 minutes.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Natural Product Chemistry
Background:
- Fast-dissolving drug delivery systems offer improved patient compliance and rapid therapeutic action.
- Natural superdisintegrants are gaining attention as cost-effective and safe alternatives to synthetic excipients.
- Aceclofenac is a widely used non-steroidal anti-inflammatory drug (NSAID) for pain and inflammation management.
Purpose of the Study:
- To formulate and optimize fast-dissolving tablets (FDTs) of Aceclofenac.
- To investigate the efficacy of Lepidium sativum mucilage as a natural superdisintegrant in FDTs.
- To optimize the formulation using a 3(2) factorial design and evaluate key performance parameters.
Main Methods:
- Aceclofenac FDTs were prepared by direct compression using varying concentrations of Lepidium sativum mucilage and β-cyclodextrin.
- A 3(2) factorial design was employed to study the effect of independent variables (mucilage and β-cyclodextrin amounts) on dependent variables (disintegration time, wetting time, in vitro drug release).
- Pre-compression blend properties, post-compression tablet characteristics, SEM, and stability studies were conducted.
Main Results:
- The factorial design effectively optimized the formulation, with formulation D5 identified as the best batch.
- Formulation D5 exhibited excellent characteristics: disintegration time (DT) of 15.5 seconds, wetting time (WT) of 18.94 seconds.
- The optimized FDTs demonstrated 100% in vitro drug release within 15 minutes, meeting desired specifications.
Conclusions:
- Lepidium sativum mucilage is a viable and effective natural superdisintegrant for formulating Aceclofenac fast-dissolving tablets.
- The direct compression method combined with factorial design offers an efficient approach for developing optimized FDTs.
- The developed Aceclofenac FDTs show promising potential for rapid onset of action and improved therapeutic outcomes.
Related Concept Videos
01:28Factors Influencing Drug Absorption: Pharmaceutical Parameters
830
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
830
01:18Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules
418
Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
418
01:23Factors Affecting Dissolution: Particle Size and Effective Surface Area
1.9K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
1.9K
01:11Oral Drug Delivery Systems: Delayed-Release Systems
206
Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
206
01:20Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
728
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
728
01:05Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
332
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
332