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Targeting the Hippo/YAP Pathway: A Promising Approach for Cancer Therapy and Beyond.

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|September 2, 2025
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Summary
This summary is machine-generated.

Targeting the Hippo pathway, crucial in cell regulation, offers promising new cancer therapies. This review explores natural and synthetic compounds for treating various cancers by modulating the Hippo/yes-associated protein (YAP) pathway.

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Hippo/Yap pathwaycancernatural productsregulationtargets

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Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • The Hippo pathway is vital for cellular processes but its dysregulation is linked to multiple cancer types.
  • Effective cancer therapies are urgently needed due to the global rise in cancer deaths.
  • Existing research on targeting the Hippo pathway for cancer treatment requires comprehensive integration.

Purpose of the Study:

  • To review the potential of targeting the Hippo/yes-associated protein (YAP) pathway for cancer therapy.
  • To provide insights into the molecular mechanisms of the Hippo pathway in physiological and cancer conditions.
  • To consolidate information on natural and synthetic compounds targeting the Hippo pathway.

Main Methods:

  • Literature review of molecular mechanisms of the Hippo signaling pathway.
  • Overview of natural products and synthetic compounds targeting the Hippo pathway.
  • Analysis of preclinical and clinical studies on Hippo pathway inhibitors in cancer.

Main Results:

  • The Hippo/YAP pathway plays a significant role in the development of various cancers.
  • Numerous natural products and synthetic compounds show potential for targeting the Hippo pathway.
  • Preclinical and clinical data suggest the efficacy of these compounds in cancer treatment.

Conclusions:

  • Targeting the Hippo/YAP pathway presents a promising therapeutic strategy for a wide range of cancers.
  • Further research into natural and synthetic compounds modulating this pathway is warranted.
  • This review highlights the therapeutic potential of Hippo pathway inhibitors in oncology.